Research
Webinars

The Human Vaccines Project and Vanderbilt University Medical Center host a monthly Influenza Webinar Series, featuring prominent scientists from laboratories around the world discussing cutting-edge influenza research. The webinar series aims to foster scientific collaboration—a necessary component of progress toward a universal influenza vaccine.

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Upcoming

August 21, 2018 | 11:00am EST
influenza webinar series
Complexity of human B cell responses to influenza vaccination
Dr. James Crowe
Vanderbilt University Medical Center
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September 18, 2018 | 11:00am EST
influenza webinar series
Dr. Paul Thomas
St Jude Children's Research Hospital
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October 16, 2018 | 11:00am EST
influenza webinar series
Dr. Scott Hensley
University of Pennsylvania
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November 20, 2018 | 11:00am EST
influenza webinar series
Dr. Adrian McDermott
NIAID
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Past Talks

July 17, 2018
influenza webinar series
Complete mapping of viral antibody-escape mutations
Dr. Jesse Bloom
Fred Hutchinson Cancer Research Center
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August 21, 2018 | 11:00am EST
influenza webinar series
Complexity of human B cell responses to influenza vaccination
Dr. James Crowe
Vanderbilt University Medical Center

Dr. Crowe’s laboratory has a broad portfolio of work in the area of viral immunology and cell biology, with an aim to discovery of mechanisms important to develop new vaccines. In addition to his own lab, Dr. Crowe directs two institutional core laboratories: the Human Immunology Core and the Flow Cytometry and Cell Sorting Core. Dr. Crowe has been the recipient of numerous investigator awards and he is an elected Fellow of AAM, AAAS, ASCI and AAP, IDSA, APS, and others. He was elected to the National Academy of Medicine in 2014.

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September 18, 2018 | 11:00am EST
influenza webinar series
Dr. Paul Thomas
St Jude Children's Research Hospital

Education

BS – Wake Forest University, Winston-Salem, North Carolina (1999)
PhD – Harvard University, Cambridge, Massachusetts (2003)

Research Interests

  • Innate and adaptive immunity to influenza
  • T cell receptor repertoires in infection and cancer
  • Influenza-associated immune-induced healing responses and pathology
  • CD8 T cell memory and recall potential
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October 16, 2018 | 11:00am EST
influenza webinar series
Dr. Scott Hensley
University of Pennsylvania

Research Interests

influenza virus
flaviviruses
zika virus
dengue virus
antigenic drift
vaccines

Description of Research at the Hensley Lab

Seasonal influenza viruses pose a major threat to the human population, contributing to over 30,000 annual deaths in the United States alone. Influenza viruses rapidly escape pre-existing humoral immunity by accumulating mutations in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). This process, termed “antigenic drift”, creates antigenically distinct viruses, making it difficult to predict which types of viruses will predominate during any given flu season. Antigenic drift is a huge problem for vaccine manufacturers.

The Hensley laboratory has 2 major scientific focuses: 1) elucidating mechanisms that promote antigenic drift of influenza viruses and 2) identifying factors that influence influenza vaccine responsiveness. Its overarching goals are to use basic immunological and virological approaches to improve the process by which influenza vaccine strains are chosen, and to develop new influenza vaccines that are protective against antigenically diverse influenza strains.

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November 20, 2018 | 11:00am EST
influenza webinar series
Dr. Adrian McDermott
NIAID

Dr. Adrian McDermott has been an experimental virologist and immunologist for over 25 years.  He has gained experience in the fields of immunogenetics, vaccinology and infectious disease immunology. He has been constantly fascinated in the hierarchy of immune responses associated with protection from viral disease and how this can be translated into vaccine design, particularly for HIV and influenza. During his tenure at the International AIDS Vaccine Initiative (IAVI) he led novel work in pre-clinical immunology, directed a large consortium dedicated to the investigation of factors associated with protection elicited by live attenuated SIVs, identified, designed and evaluated unique replicating vector platforms for delivery of T and B cell immunogens. He also extended his post-doctoral work with Dr. David Watkins, which developed the low dose-multiple exposure SIV NHP challenge model for the improved assessment of vaccines in the face of virus challenge. This work has been subsequently standardized and widely employed, as the ‘SIV acquisition model’, which allows the evaluation of HIV vaccine strategies in terms of ‘protection from multiple exposures’ in the NHP.  Since arriving at the Vaccine Research Center (VRC)-NIH in 2011, Dr. McDermott has directed the Immunology Core Laboratory and currently leads a multi-disciplinary program that performs basic vaccine discovery B cell research through to the assessment and clinical evaluation of lead vaccine candidates.  His group has published in-depth analyses of influenza and HIV vaccine strategies, which are aimed at the discovery and development of a safe, effective vaccines.

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July 17, 2018
influenza webinar series
Complete mapping of viral antibody-escape mutations
Dr. Jesse Bloom
Fred Hutchinson Cancer Research Center

Jesse Bloom is an Associate Member in Basic Sciences and Computational Biology at the Fred Hutchinson Cancer Research Center, and a HHMI-Simons Faculty Scholar. His group uses a mix of experimental and computational approaches to study viruses and their evolution.

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