The following articles cover important research around COVID-19 and the development of antibody therapies.
- In a pre-print review article, Huang et al. summarize research on antibody immunity to coronaviruses including 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence.
- Korber et al. have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-CoV-2, focusing initially on the Spike (S) protein. Their findings have important implications for SARS-CoV-2 transmission, pathogenesis and immune interventions.
- Hachim et al. in a pre-published article look beyond the spike to consider new viral targets of antibody responses in COVID-19 patients.
- On the topic of antibodies, biologists have advanced new research on miniature antibodies derived from llamas and other species that could have advantages in speed, cost and pathogen binding when compared to human or mouse antibodies, opening new avenues to combat future pandemics.
- Padron-Regalado looks for lessons learned from vaccine development for other coronavirus strains, including MERS-CoV and SARS-CoV-1.