University of Pennsylvania
Dr. E. John Wherry is the Barbara and Richard Schiffrin President’s DistinguishedProfessor, Chair of the Department of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine and Director of the UPenn Institute for Immunology. Dr. Wherry received his Ph.D. at Thomas Jefferson University in 2000 then did postdoctoral research at Emory University with Dr.Rafi Ahmed from 2000-2004. Dr. Wherry has received numerous distinctions and honors including the Distinguished Alumni Award from the Thomas Jefferson University, the Cancer Research Institute’sFrederick W.Alt Award for New Discoveries in immunology and the Stand Up To Cancer Phillip A. Sharp Award. Dr. Wherry has over 225 publications. He has an H-Index of101and his publications have been cited over 55,000 times. Dr.Wherry’s research has pioneered the field of T cell exhaustion – the fundamental mechanisms by which T cell responses are attenuated during chronic infections and cancer. His discoveries helped identify the role of PD-1 and the ability to block this pathway to reinvigorate exhausted T cells. His group also first demonstrated that targeting multiple co-inhibitory receptors simultaneously could synergistically improve therapeutic efficacy, a foundation for current combination immunotherapy efforts in humans. Dr. Wherry’s work has defined the transcriptional and epigenetic atlas of exhausted T cells defining exhausted T cells as a distinct immune lineage. Finally, his laboratory has been a pioneer in defining the concept of Immune Health using systems immunology approaches, most recently applying this concept to COVID-19.