Vaccines have been one of the most effective public health interventions over the last century, preventing and controlling a broad spectrum of infectious diseases [1Centers for Disease C, Prevention. Control of infectious diseases. MMWR Morb Mortal Wkly Rep. 1999;48:621–629.]. Recent scientific and technological breakthroughs suggest an even greater potential for vaccines and immune-driven therapies for diseases ranging from complex pathogens and cancers to allergies and autoimmune diseases. Still, continued and significant public health advances are being held back by a lack of understanding of how best to exploit the human immune system to confer specific and durable protective immune responses.
W. C. Koff and T. Schenkelberg (2016)