Research
Webinars

The Human Vaccines Project and Vanderbilt University Medical Center host a monthly Influenza Webinar Series, featuring prominent scientists from laboratories around the world discussing cutting-edge influenza research. The webinar series aims to foster scientific collaboration — a necessary component of progress toward a universal influenza vaccine.

Select presentations from the 2018 Future of Vaccine Discovery Conference can be found below and a complete collection of the presentations can be found HERE.

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Upcoming

Past Talks

May 21, 2019
influenza webinar series
Unraveling the Mechanism of Influenza Vaccine-Induced Immunity Through Systems Vaccinology
Dr. Helder Nakaya
University of Sao Paulo, Brazil
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April 16, 2019
INFLUENZA WEBINAR SERIES
Seeing is believing: From intracellular influenza viral RNA assembly to persistence of influenza viruses in aerosols
Dr. Seema Lakdawala
University of Pittsburgh
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March 19, 2019
influenza webinar series
Monitoring B cell response to immunogens, one cell at a time…
Dr. Adrian McDermott
NIAID
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February 19, 2019
influenza webinar series
Connecting single-cell gene expression with B cell receptor specificity
Dr. Aly Khan
Toyota Technological Institute at Chicago
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January 15, 2019
influenza webinar series
Immune responses to influenza A/H1N1pdm09 virus after adjuvanted pandemic and seasonal influenza vaccination in healthcare workers: a five-year follow-up study
Dr. Rebecca Cox
University of Bergen
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October 16, 2018
influenza webinar series
Immune History and Influenza Virus Susceptibility
Dr. Scott Hensley
University of Pennsylvania
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September 18, 2018
influenza webinar series
Host immune and genetic factors that regulate outcomes in influenza infection
Dr. Paul Thomas
St Jude Children's Research Hospital
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August 21, 2018
influenza webinar series
Complexity of human B cell responses to influenza vaccination
Dr. James Crowe
Vanderbilt University Medical Center
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July 17, 2018
influenza webinar series
Complete mapping of viral antibody-escape mutations
Dr. Jesse Bloom
Fred Hutchinson Cancer Research Center
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June 27, 2018
James E Crowe The Human Immunome
James E Crowe
Vanderbilt University
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June 27, 2018
Michelson Prize Winner Laura Mackay
Laura Mackay
University of Melbourne
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June 27, 2018
Michelson Prize Winner Ansuman Satpathy
Ansuman Satpathy
Stanford University
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June 27, 2018
Michelson Prize Winner Patricia Illing
Patricia Illing
Monash University
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May 21, 2019
influenza webinar series
Unraveling the Mechanism of Influenza Vaccine-Induced Immunity Through Systems Vaccinology
Dr. Helder Nakaya
University of Sao Paulo, Brazil
April 16, 2019
INFLUENZA WEBINAR SERIES
Seeing is believing: From intracellular influenza viral RNA assembly to persistence of influenza viruses in aerosols
Dr. Seema Lakdawala
University of Pittsburgh
March 19, 2019
influenza webinar series
Monitoring B cell response to immunogens, one cell at a time…
Dr. Adrian McDermott
NIAID

Dr. Adrian McDermott has been an experimental virologist and immunologist for over 25 years.  He has gained experience in the fields of immunogenetics, vaccinology and infectious disease immunology. He has been constantly fascinated in the hierarchy of immune responses associated with protection from viral disease and how this can be translated into vaccine design, particularly for HIV and influenza. During his tenure at the International AIDS Vaccine Initiative (IAVI) he led novel work in pre-clinical immunology, directed a large consortium dedicated to the investigation of factors associated with protection elicited by live attenuated SIVs, identified, designed and evaluated unique replicating vector platforms for delivery of T and B cell immunogens. He also extended his post-doctoral work with Dr. David Watkins, which developed the low dose-multiple exposure SIV NHP challenge model for the improved assessment of vaccines in the face of virus challenge. This work has been subsequently standardized and widely employed, as the ‘SIV acquisition model’, which allows the evaluation of HIV vaccine strategies in terms of ‘protection from multiple exposures’ in the NHP.  Since arriving at the Vaccine Research Center (VRC)-NIH in 2011, Dr. McDermott has directed the Immunology Core Laboratory and currently leads a multi-disciplinary program that performs basic vaccine discovery B cell research through to the assessment and clinical evaluation of lead vaccine candidates.  His group has published in-depth analyses of influenza and HIV vaccine strategies, which are aimed at the discovery and development of a safe, effective vaccines.

February 19, 2019
influenza webinar series
Connecting single-cell gene expression with B cell receptor specificity
Dr. Aly Khan
Toyota Technological Institute at Chicago

Aly Khan is a Research Assistant Professor at the Toyota Technological Institute at Chicago. His research interests are in computational biology and bioinformatics, with a focus on developing novel computational and statistical methods to study the molecular and cellular systems that control immune function. In particular, he is interested in using non-parametric statistics, optimization, and related areas of machine learning to overcome many of the data-intensive roadblocks currently facing immunology. In addition to his academic research, he has spent some time developing computational algorithms to improve drug target discovery at Merck, and designed statistical models to analyze market impact as a Summer Associate on the program trading desk at Bank of America.

Dr. Khan received his PhD from Cornell University in 2012, where he completed his graduate studies in computational biology in a joint program with Memorial Sloan Kettering Cancer Center. From 2012 to 2014 he was a fellow at the Institute for Genomics and Systems Biology at the University of Chicago.

January 15, 2019
influenza webinar series
Immune responses to influenza A/H1N1pdm09 virus after adjuvanted pandemic and seasonal influenza vaccination in healthcare workers: a five-year follow-up study
Dr. Rebecca Cox
University of Bergen

Rebecca Cox is professor in medical virology and head of the Influenza Centre at the University of Bergen, Norway. Rebecca Cox completed her PhD in 1995 at the London Hospital Medical College, University of London, UK on the immune response to influenza. She then had post doc positions at Guys Hospital, UK and the University of Bergen. Her research has focused on preclinical and clinical evaluation of seasonal and pandemic influenza vaccines and in depth understanding of the immune response. Her research has been funded by grants from the European Union, The Research Council of Norway, the Norwegian Directorate of Health and the University of Bergen. She is a board member and secretary of the Influenza and Other Respiratory Viruses society. She sits on the Norwegian Pandemic and epidemic committee and the WHO SAGE influenza Working Group.

October 16, 2018
influenza webinar series
Immune History and Influenza Virus Susceptibility
Dr. Scott Hensley
University of Pennsylvania

Research Interests

influenza virus
flaviviruses
zika virus
dengue virus
antigenic drift
vaccines

Description of Research at the Hensley Lab

Seasonal influenza viruses pose a major threat to the human population, contributing to over 30,000 annual deaths in the United States alone. Influenza viruses rapidly escape pre-existing humoral immunity by accumulating mutations in the viral surface proteins hemagglutinin (HA) and neuraminidase (NA). This process, termed “antigenic drift”, creates antigenically distinct viruses, making it difficult to predict which types of viruses will predominate during any given flu season. Antigenic drift is a huge problem for vaccine manufacturers.

The Hensley laboratory has 2 major scientific focuses: 1) elucidating mechanisms that promote antigenic drift of influenza viruses and 2) identifying factors that influence influenza vaccine responsiveness. Its overarching goals are to use basic immunological and virological approaches to improve the process by which influenza vaccine strains are chosen, and to develop new influenza vaccines that are protective against antigenically diverse influenza strains.

September 18, 2018
influenza webinar series
Host immune and genetic factors that regulate outcomes in influenza infection
Dr. Paul Thomas
St Jude Children's Research Hospital

Education

BS – Wake Forest University, Winston-Salem, North Carolina (1999)
PhD – Harvard University, Cambridge, Massachusetts (2003)

Research Interests

  • Innate and adaptive immunity to influenza
  • T cell receptor repertoires in infection and cancer
  • Influenza-associated immune-induced healing responses and pathology
  • CD8 T cell memory and recall potential

August 21, 2018
influenza webinar series
Complexity of human B cell responses to influenza vaccination
Dr. James Crowe
Vanderbilt University Medical Center

Dr. Crowe’s laboratory has a broad portfolio of work in the area of viral immunology and cell biology, with an aim to discovery of mechanisms important to develop new vaccines. In addition to his own lab, Dr. Crowe directs two institutional core laboratories: the Human Immunology Core and the Flow Cytometry and Cell Sorting Core. Dr. Crowe has been the recipient of numerous investigator awards and he is an elected Fellow of AAM, AAAS, ASCI and AAP, IDSA, APS, and others. He was elected to the National Academy of Medicine in 2014.

July 17, 2018
influenza webinar series
Complete mapping of viral antibody-escape mutations
Dr. Jesse Bloom
Fred Hutchinson Cancer Research Center

Jesse Bloom is an Associate Member in Basic Sciences and Computational Biology at the Fred Hutchinson Cancer Research Center, and a HHMI-Simons Faculty Scholar. His group uses a mix of experimental and computational approaches to study viruses and their evolution.

June 27, 2018
James E Crowe The Human Immunome
James E Crowe
Vanderbilt University

Overview of the complexity of the human immunome

June 27, 2018
Michelson Prize Winner Laura Mackay
Laura Mackay
University of Melbourne

Targeting tissue-resident immune cells for enhanced immune protection

June 27, 2018
Michelson Prize Winner Ansuman Satpathy
Ansuman Satpathy
Stanford University

3D and single-cell epigenome technologies for precision immune profiling

June 27, 2018
Michelson Prize Winner Patricia Illing
Patricia Illing
Monash University

Exploring a role for spliced peptides in anti-viral immune responses

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